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Most people experience mild to moderate constipation that improves with lifestyle modifications, though some patients may need additional support

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Concurrently, disruptions in intracellular ATP and K + homeostasis elevate reactive oxygen species (ROS) levels, damage mitochondrial DNA (mtDNA), and promote the recruitment of NIMA-related kinase 7 (NEK7) to bind and activate the NLRP3 inflammasome

Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219