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doi:10.1186/s12958-018-0418-y Higdon J

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This mechanism is an attractive hypothesis to explain how metformin mediates a multitude of cellular effects via AMPK (100)

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Step 3: Hydrate

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demonstrated that CNS leptin administration normalized myocardial fatty acid oxidation, and improved glucose oxidation and mitochondrial function in hearts of leptin-deficient ob/ob mice, and this effect was independent of caloric intake and reduction in body weight [24]

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Wolffenbuttel, Department of Endocrinology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands

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