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If you are a regular smoker, when the blood level of nicotine falls, you usually develop withdrawal symptoms such as craving, anxiety, restlessness, headaches, irritability, hunger, difficulty with concentration, or just feeling awful

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Ellickson PL et al, High-risk behaviors associated with early smoking: results from a 5-year follow-up, J Adolesc Health, 2001 June;28(6):465-73 12

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This metric is particularly important as it correlates with the risk of developing smoking-related diseases such as lung cancer, chronic obstructive pulmonary disease (COPD), and heart disease