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335 Moreover, androgens decrease the type I muscle fibers (TIMF) with highly oxidative and insulin-sensitive properties, while increase type II muscle fibers (TIIMF) that are glycolytic and less insulin-sensitive, further decreasing glycogen synthase expression and favoring the development of IR in PCOS

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A novel mechanism for pergolide-induced neuroprotection: Inhibition of NF-kappaB nuclear translocation

Not only does this treatment failure burden the healthcare system with excess costs, it can also be devastating for patients who end up right back where they started