9:00 - ASSAY DEVELOPMENT FOR PYRUVATE DEHYDROGENASE KINASE INHIBITOR DISCOVERY Nathan Lilla University of Nebraska at Kearney Pyruvate dehydrogenase kinase (PDK) regulates the activity of the pyruvate dehydrogenase complex (PDC) by phosphorylating its E1 subunit, thereby limiting conversion of pyruvate to acetyl-CoA, restricting entry into the TCA cycle, and reducing ATP production
Duration versus intensity of exposure on the risk of lung cancer due to radon exposure in the general population
How long does the patient need to participate in lifestyle intervention before the PA
Social Media & Marketing Manager Victoria Voos Victoria Voos Social Media & Marketing Manager Victoria is the creative mind behind Vineyards social media, blending education with humor to make metabolic health relatable and approachable
Understand their synthesis process
Stomach Pain on Reta vs Other GLP-1 Compounds Cross-trial comparisons have significant limitations, but directional data helps contextualize the stomach pain experience on retatrutide: Metric Retatrutide 12 mg Semaglutide 2.4 mg Tirzepatide 15 mg Overall GI events ~67% ~74% ~51% Nausea ~46% ~44% ~31% Diarrhea ~33% ~30% ~23% Vomiting ~22% ~24% ~12% Discontinuation due to GI AEs ~8% ~7% ~6% Key observation: Despite targeting three receptors instead of one or two, retatrutide's overall GI adverse event rate is comparable to semaglutide and modestly higher than tirzepatide
