TRIUMPH-5: type 2 diabetes, active-comparator design
doi: 10.1002/jcp.20339 6 WangALuanHHMedzhitovR
To enhance the tumor targeting of liposomes, the CKAAKN peptide was conjugated to DSPE-PEG 2000 -NH 2 via an amidation reaction
However, smaller nanoparticles are prone to agglomeration and rapid excretion through the kidneys, evading liver uptake and reducing the circulation time in the body, ultimately diminishing the therapeutic efficacy [20]
Another study showed that active tablets containing calcium butyrate (500 mg/tablet), zinc gluconate (zinc 5 mg/tablet), and vitamin D3 (500 IU/tablet) improved liver steatosis and several NAFLD-related parameters [146]
As oxidative stress and neuroinflammatory pathways have considerable crosstalk (See Scheme 1), there is an unmet need for further research exploring this relationship in the pathophysiology of epilepsy