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In controlled trials, the dose that works is an empirical question with a real answer, not a number you push upward until you feel something

19 We speculate that patients with clEDS may be more prone to have structural defects along the walls of the gastrointestinal tract, which can predispose to diffuse diverticulosis, diverticulitis, and resulting bowel perforation as well as to perforation during invasive procedures and spontaneous perforation

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There were no changes in those treated with PAGln (Fig

Although this difference is not optimal for comparison to the field tests, it was necessary so that the certificate is issued according to the current standard and thereby relevant for ENERCON and for the industry in general