On a therapeutic note, some microbiota-targeted treatments have reduced protein aggregates in models: long-term broad-spectrum antibiotics reduced A deposition and microglial reactivity in an AD mouse model, and recolonization with a simplified microbiota reversed some of these effects, indicating that specific microbial communities can either exacerbate or ameliorate protopathic cascades [102]
Clinical studies support this: exposure to diesel exhaust particles (DEPs) reduces peroxisomal ACOX1 expression in bronchial epithelial cells from asthma patients (105), exacerbating PUFA accumulation and ferroptosis
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