The result is a two-pronged stimulus: one from the gut telling the brain the stomach is overly full, and one from the drug acting on the brain itself
And surgery works through some of the same hormonal mechanisms as GLP-1 drugs: One of the reasons researchers first identified GLP-1 as important was that bariatric surgery dramatically increases the bodys own GLP-1 levels
The Medicines and Healthcare products Regulatory Agency (MHRA), shared data showing hundreds of cases of acute and chronic pancreatitis among people taking GLP-1 medicines since the drugs were first licensed
It found a 20% reduction in major adverse cardiovascular events - heart attacks, strokes, and cardiovascular death - with FDA-approved Wegovy in a population with established cardiovascular disease and overweight or obesity
Should you stop the medication if retinopathy worsens
two patients discontinued due to nausea Takeaway: Lower doses may improve tolerability, though weight loss trailed standard dosing