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have investigated the apparent selectivity of FOXO4-DRI peptide in regard to specifically targeting aged cells for apoptosis

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Further Western blot analysis showed that RRM2 regulated the expression levels of MMP2, MMP9 and EMT-related proteins (N-Cadherin, Vimentin, Snail), suggesting that RRM2 may promote tumor cell invasion and metastasis by promoting matrix degradation and inducing epithelial mesenchymal transition