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In women, higher BMI (body mass index) is linked with: Irregular or absent periods and anovulation

Necrotic bone stimulates proinflammatory responses in macrophages through the activation of toll-like receptor 4

The cell plasma membrane exhibits increased selective permeability, Na+/K+-ATPase, and Ca2+-ATPase activity, leading to the accumulation of sodium-dominated ions and water in cells as a precursor of ionic edema [73, 76, 77]