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Fatigue was assessed by using a validated Fatigue Assessment Scale (FAS), a self-questionnaire that provides a subjective measurement of fatigue severity and has shown to have a high degree of internal consistency, validity, and sensitivity to changes in clinical condition (26)

SC administration offers practical advantages: Potential for self-injection at home No requirement for clinical infusion center Simpler logistics for chronic dosing Better patient compliance for long-term treatment Clinical Trial Dosing# COURAGE Trial (Phase 2, Obesity)# COURAGE Triplet Arm# Phase 1 Trial (NCT02943239)# Dose Comparison Across Studies# Dosing Considerations# No Clear Dose-Response for Trevogrumab Alone# In the COURAGE trial, both the 200 mg and 400 mg trevogrumab doses showed remarkably similar lean mass preservation (50.8% vs 51.3%), suggesting that myostatin blockade alone may have a ceiling effect

Higher doses are more expensive, and if you're achieving your weight loss goals on a lower dose, it may not be necessary to move up

Common Topical Application Patterns Use case Facial anti-aging (community use) Concentration 1-2% Frequency Once or twice daily Cycle length 8-12 weeks Use case Scalp / hair-research interest Concentration 1-3% Frequency Daily Cycle length 12+ weeks ongoing Use case Compounded post-procedure Concentration 1-2% Frequency Per clinician guidance Cycle length Per clinician guidance Topical concentrations are typically expressed as percent weight

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24:34: When you do an experiment, you learn how you screwed up if you're a good scientist because, by definition, you're always doing something no one's ever done before because it's boring to do stuff that people have done before