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Fermentation also helps to reduce the harshness and bitterness of the tobacco, making it more enjoyable to smoke or use in other tobacco products.While fermentation is an important step in the tobacco curing process, it is important to note that tobacco products still contain nicotine and other harmful chemicals that can be addictive and harmful to health

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Balaji G, Maharani B, Ravichandran V, Parthasarathi T

DAO uses copper as a cofactor and requires vitamin B6 (in its P5P form) to function optimally. 24 Multiple SNPs in AOC1 have been associated with significantly reduced DAO activity and histamine intolerance