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Broad Institute connectivity map analysis showed a net directional shift toward younger expression patterns upregulating DNA repair, antioxidant response, and collagen synthesis while suppressing genes associated with tissue degradation and inflammation
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In both cases, cancer cells displayed morphological changes, increased SA--Gal activity, and elevated p53 and p21 levels following treatment [80]
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When cellular energy levels drop, AMPK is activated to stimulate energy-generating processes while halting energy-consuming ones, effectively forcing the cell to restore its energy balance
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