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Ceritinib-induced regression of an insulin-like growth factor-driven neuroepithelial brain tumor

A pilot study assesses the efficacy of a new eye drop formulation that integrates hyaluronic acid (HA) and mallow extract ( Malva sylvestris ) for the treatment of DED

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high dose did not Onset : Cognitive enhancement observed within 4 hours Duration : Effects persisted for approximately 2 weeks Limitations of Preclinical Dosing Data# Several critical factors prevent translation of animal dosing to human use: No human PK data : Pharmacokinetic parameters for klotho peptides in humans are completely unknown Species differences : Peptide metabolism, distribution, and receptor binding may differ significantly between rodents and humans Route challenges : IV injection and chronic infusion used in preclinical studies require adaptation for clinical use Dose-response : KP1 and KP6 dose-response relationships have not been fully characterized even in animal models Peptide stability : In vivo half-life and proteolytic degradation rates not formally established No Commercial Products Available# Klotho peptides are not available as dietary supplements, injectable peptides, or any other consumer product

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Science 347 , 14651470 (2015)