In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]
Some other risk factors include starting treatment too quickly or increasing the dose faster than recommended
As a long-acting analog of human IGF-1, it is engineered to deliver more substantial and more sustained receptor activity, driving muscle growth, tissue regeneration, and metabolic enhancement
Best practice in statistics: the use of log transformation
Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle
Data availability The de-identified electronic medical record data that support the findings of this study are available from the Asan Biomedical Research Environment (ABLE) database at Asan Medical Center, Seoul, Republic of Korea
