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Researchers administering cisplatin (5 mg/kg) to rats found marked toxic effects related to the dosage and timing in relation to their sexual cycle ( 4 Effective strategies to prevent the POF induced by cisplatin Due to the significant renal toxicity of cisplatin therapy, pre-treatment hydration therapy must be initiated before the treatment ( For gastrointestinal toxicity causing nausea and vomiting, antiemesis drugs can be used before the medication, a four-drug combination regimen consisting of NK1 receptor antagonist, 5-HT3 receptor antagonist, dexamethasone, and olanzapine has been recommended by the American Society of Clinical Oncology guidelines ( For hematological toxicity, granulocyte colony stimulating factor (G-CSF), recombinant human platelet growth factor, erythropoietin (EPO) and other drugs can be used to treat the symptoms, the chemotherapy doses can be adjusted, or blood transfusions may be required ( The neurotoxicity caused by cisplatin treatment cannot be avoided

2.4.1 The antagonistic roles of CHAC1 and CHAC2 in stem cell regulation The function of CHAC1 is further refined by its competitive interaction with its homolog, CHAC2

Read, and F.J

& Deepa, S

C.EderA.PresenhuberC.NellA.SperrW.et al (2006)

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