J Biol Chem 280:2530525312 Knollema S, Hom HW, Schirmer H, Korf J, Ter Horst GJ (1996) Immunolocalization of glutathione reductase in the murine brain
Accepted reasons for clinical necessity include: Intolerance to GI side effects requires a low-dose titration schedule not available commercially Need for split dosing across two or three weekly injections at doses not available commercially Allergy or sensitivity to an inactive ingredient in the commercial formulation, such as benzyl alcohol, excipients, or preservatives Requirement for a preservative-free formulation Therapeutic-additive requirements, such as leucine, methylcobalamin (B12), pyridoxine (B6), or L-carnitine A specific dose strength or concentration not available in any commercial format An alternative delivery method or dosage form not available commercially The clinical necessity must be explicitly documented on the prescription by the ordering prescriber
B12 is naturally present in many animal-derived foods like meat, fish, and certain cheeses
The second week comes, and they continue to take it daily
those with a code for type 1 diabetes or gestational diabetes were excluded
doi: 10.1210/jcem.80.2.7852523 51 De Lind van WijngaardenRFAOttenBJFestenDAMJoostenKFMde JongFHSweepFCGJet al
