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Recognizing the significant weight loss potential of semaglutide, the FDA later approved Wegovy (semaglutide) specifically for chronic weight management in adults with obesity (BMI 30 kg/m) or who are overweight (BMI 27 kg/m) and have at least one weight-related comorbidity, such as high blood pressure, type 2 diabetes, or high cholesterol

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Both are GLP-1 receptor agonists used for weight loss, but tirzepatide also activates GIP receptors, giving it a dual mechanism

10.1016/j.cmet.2025.06.009 143 TremblayA.AugerJ.AlyousifZ.CaleroS