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In a multicenter PPMI cohort, free water in the posterior region of the SN increased in de novo PD from baseline to 1, 2, and 4 years, and changes in free water within 1 year predicted changes in the Hoehn & Yahr scale at 4 years (Burciu et al., 2017)

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Ini artinya, radikal bebas merupakan proses yang tidak terhindarkan

They are bioactive molecules with characterized mechanisms of action, published clinical data, and, in many cases, FDA approval