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I'm one of them, and as I can attest, the results can be dramatic: In clinical trials, people taking these medications often lose a substantial amount of weight, though outcomes vary by drug, dose and individual

Given the induction of membrane and nuclear PR expression along with other steroid hormone receptors in response to semaglutide + levonorgestrel (Figure 2), hormone responsiveness is potentially magnified even in cases that initially express low PR levels and would be considered to be hormone therapy-unresponsive using a progestin alone

While both paths can be effective, they arent interchangeable

Whether to stop remains a prescriber's call

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A press release from the U.S