The addition of GIP receptor activation in Retatrutide appears to improve tolerability rather than worsen it, which is consistent with what was observed in the shift from Semaglutide to Tirzepatide
10.1385/1-59259-762-9:383 51 BernadoP.SvergunD
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10.1210/endrev/bnac033 11 DarbalaeiS.ChangR
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Digoxin (Lanoxin) Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias