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Lancet 396 , 18171828 (2020)

PMID 8331657

In parallel, luteolin enhances apoptosis in aberrantly proliferative tissues through activation of caspase-3, -8, and -9, disruption of mitochondrial membrane potential, and induction of DNA fragmentation ( 5.4 Modulation of the PI3K/AKT/PTEN survival and metabolic pathway The PI3K/AKT/PTEN axis integrates metabolic control, cell survival, and growth factor responses in reproductive tissues (Rascio et al., 2021)

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