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Galli M, Hameed A, bikowski A, Zabielski P (2021) Aquaporins in insulin resistance and diabetes: more than channels
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PTEN deficiency activates the PI3K signaling pathway, which promotes the expansion of a specific population of resident-like macrophages in omental tumors ( Figure 1 ) ( Figure 1 Wnt/-catenin signaling The Wnt/-catenin signaling pathway is essential for promoting macrophage M2 polarization, which plays a significant role in ovarian cancer progression ( Figure 1 ) ( NF-KB pathway Enhanced canonical NF-kappaB signaling in macrophages is enough to reduce tumor progression in syngeneic mouse models of ovarian cancer by fostering an anti-tumor immune environment ( Another key example of this NF-B-driven interplay between ovarian cancer cells, macrophages, and the tumor microenvironment is seen with periostin (POSTN), a matrix protein overexpressed in highly invasive ovarian cancer cells ( When ovarian cancer cells are exposed to M1 macrophage-conditioned media, their migration and invasion abilities significantly increase, which are key factors in metastasis ( Figure 2 ) ( Figure 2 STAT signaling Alternatively activated macrophages (AAMs) promote the metastasis of ovarian cancer by secreting factors like FLT3L, leptin, and HB-EGF, which stimulate the spreading of HGSOC spheroids across the extracellular matrix (ECM)
