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In one case, a 60-year-old male subject experienced drastically elevated heart rate and blood pressure after injecting 10mg of melanotan 2 in a single day

Once-daily administration of PF-06882961 for 2 days also inhibited food intake compared to vehicle-treated monkeys (Fig

10.1002/mrd.20137 Mol Reprod Dev

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Trends Neurosci 2:174177

Furthermore, the Endocrine Societys obesity guideline recommends that patients with obesity in the absence of diabetes should discontinue weight-loss medications if safety or tolerability issues arise, and consider other therapeutic options