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Bile acid sequestrants (BASs) are anion exchange resins that prevent ileal uptake of bile acids by trapping BAs in the intestinal lumen, resulting in induced de novo synthesis of bile acids from cholesterol in the liver, which decreases plasma cholesterol

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This leads to erratic heart rates, blood pressure instability, and severe gastrointestinal symptoms

Observational studies of people with diabetes [47, 48] that addressed immortal time bias [34] found no association between dementia risk and initiation of metformin, a first-line therapy for type 2 diabetes

Moderate hyperhomocysteinaemia and immune activation in patients with rheumatoid arthritis