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Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

For mild cases, several home remedies can alleviate symptoms: Warm Baths: Soaking in warm water can reduce discomfort and soothe the anal area

cardiovascular outcome data (SELECT trial)

Multiple studies show that serial corticosteroid injections are associated with tendon degeneration, reduced collagen quality, and increased risk of tendon rupture

Current therapeutic development focuses on either recombinant protein formulations (Jocasta Neurosciences JN-0413) or mRNA-based approaches to stimulate endogenous production (Klothea Bio)