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Decoding immune resistance in MSS CRC: the role of metabolicimmune crosstalk Immune checkpoint inhibitors (ICIs) have demonstrated significant efficacy in patients with microsatellite instability-high (MSI-H) CRC, yet their therapeutic benefit remains limited in the majority of cases, which are microsatellite stable (MSS) [80]

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- The Physicians Health Study II (14,000+ participants over 11 years) found that multivitamins did not reduce heart attacks, strokes, or overall mortality [PMID: 23117775]

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