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Furthermore, Ras-selective lethal 3 (RSL3) and the 5,6-dihydro-2H-pyrano[3,2-g]indolizine (DPI) class of luminogen (DPI, also known as ML162) are known as class 2 ferroptosis inducers that directly inhibit GPX4 enzymatic activity [91,93]

[DOI] [PubMed] [Google Scholar] 64.Yazaki K

4 Necroptosis in CP-induced acute kidney injury (AKI) 4.1 Fundamentals of necroptosis 4.1.1 General overview of necroptosis The term programmed cell death had been commonly used to describe caspase-dependent apoptosis until caspase-independent necrosis was identified (Linkermann et al., 2012)