In the Semaglutide Treatment Effect in People with Obesity (STEP)-1 trial [13], there was a statistically significant weight loss in the 2.4 mg semaglutide group compared to the placebo group, with a 14.9% reduction in body weight from baseline in the semaglutide group and 2.4% reduction in the placebo group
During the same period, obesity without T2DM notably increased from 10 to 31%
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Injection-site reactions and worsening of pre-existing diabetic retinopathy are also relevant clinical concerns
For this reason, we did an inverse probability of censoring weighting sensitivity analysis, which yielded point estimates that were very similar to those of the primary analysis