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Researchers found that those in the treatment group had a greater decrease in kidney function and an increase in vascular events, including heart attack and stroke

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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

Methods Enzymol 348:93112 Holmgren A, Sengupta R (2010) The use of thiols by ribonucleotide reductase