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The peptide works through cumulative effects on follicle function, not immediate action

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The result is impaired BH4 recycling less BH4 available to maintain eNOS in its coupled, NO-producing configuration independent of the direct homocysteine-mediated BH4 oxidation described above

doi: 10.1177/1352458514544537 77 CampbellGRZiabrevaIReeveAKKrishnanKJReynoldsRHowellOet al

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doi: 10.1016/j.bbi.2021.10.018 57 ParkCBrietzkeERosenblatJDMusialNZuckermanHRagguettR-Met al