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Diabetes and weight-loss trials have shown that the GLP-1 drugs target hormones in the gut and the brain that control appetite and feelings of fullness, cutting down on what's described as food noise, or intrusive thoughts of food

About the Author: Jack Mountain, PharmD Jack Mountain, PharmD, is completing a post-graduate year two (PGY-2) pharmacy residency in ambulatory care at Rhode Island Hospital

January 29, 2025

In fact, Nourish noted in the funding announcement that payers are under growing pressure to find scalable solutions that actually bend the cost curve." The financial strain of GLP-1s is two-fold: payers battle the sheer sticker shock of these medications and the sunk costs when patients discontinue treatment

And hepatic steatosis resolved in greater than 85% of participants with retatrutide 8 mg and 12 mg at week 48. The safety profile of retatrutide in the NAFLD subset was similar to that in the obesity population, and no hepatotoxicity signals in obesity or NAFLD was seen through week 48

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