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In the liver, vitamin B12, like vitamin B6, promotes theprotein metabolism in the endoplasmic reticulum

It is acknowledged that the stimulation of signal transducers and activators of transcription 3 (STAT3) is essential for the transformation into the M2 subtype, whereas the activation of STAT1 is a crucial determinant for the M1 subtype [85]

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Sulforaphane, generated from glucoraphanin upon chopping or chewing, potently activates the Nrf2 transcriptional pathway, increasing glutathione synthesis and enhancing neuronal resilience against oxidative injury (171176)

What are some natural dietary sources of Vitamin B12

During activation, microglia typically upregulate proteins such as TREM2, APOE, and TYRO protein tyrosine kinase-binding protein (TYROBP)