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One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30

Chewing tobacco 10 or more times a day increased the risk of oral cancer 9.2 times [15,16] whereas products including gutka and supari increased the risk by 7.3 and 4 respectively [17]

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Addiction, 116 (7), 16221630