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Although several studies have indicated that the novel antidiabetic drugs, including sodium glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase 4 inhibitors (DPP4i) provide the cardiovascular benefits in T2DM patients with HFpEF, the elaborated roles and mechanisms are not fully understood

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The goal is successful maintenance, not speed

Plasma GLP-1 is increased and this is responsible in part for weight loss and metabolic improvement which occurs before weight loss (55) 2