evoke semaglutide trial When GLP-1s become brain drugs A Critical Appraisal of the

Report any suspected side effects via the MHRA Yellow Card Scheme

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In the STEP-1 clinical trial published in the New England Journal of Medicine , participants lost an average of 15% of their body weight over 68 weeks

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However, FDA prescribing information recommends considering discontinuation for sustained significant increases in resting heart rate, and patients with persistent palpitations or heart rate above 100 bpm should consult their healthcare provider