Dipeptidyl peptidase-4 inhibitor anagliptin facilitates restoration of dextran sulfate sodium-induced colitis
Acetylated L-carnitine crosses the blood-brain barrier via membrane receptors to enter the brain and be converted into GABA
This selectivity profile is why Ipamorelin replaced first-generation GHRPs as the preferred ghrelin-receptor agonist in clinical practice
Several GLP-1R peptide-based agonists including liraglutide, semaglutide, dulaglutide, and tirzepatide (a dual GLP-1R/GIPR agonist) have been approved for the treatment of obesity and type 2 diabetes, achieving unprecedented improvements in glycemic control and body weight reduction (Arslanian et al., 2022
Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy
Furthermore, semaglutide is stabilized against degradation by the DPP-4 enzyme