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FASEB J 24:25332545 Jones DP (2006) Redefining oxidative stress

The dosage with 2 mg/kg had no effect

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In addition to Ca 2+ -calmodulin regulation, CaMKK2 is also regulated by phosphorylation of the S3-node, which is a control switch in the N-terminal regulatory sequence of CaMKK2 composed of three tandem serine residues (S3) that are sequentially phosphorylated by cyclin-dependent protein kinase-5 (CDK5) and glycogen synthase kinase-3 (GSK3) [40]