incretin mimetic agents glp 1 receptor agonists Incretins: How we got here, where we're at and what is coming next The protective role of GLP-1

2013 Oct 18;14(10):21021-44

No dedicated pharmacokinetic studies exist for these drugs combined with GLP-1 RAs

**Quick calculator (30mg vial at 10mg/ml):** | Weekly Dose | Volume per Injection | Syringe Units | Doses per Vial | |------------|---------------------|---------------|----------------| | 1mg | 0.10ml | 10 units | 30 doses | | 2mg | 0.20ml | 20 units | 15 doses | | 4mg | 0.40ml | 40 units | 7.5 doses | | 8mg | 0.80ml | 80 units | 3.75 doses | | 12mg | 1.20ml | Split: 60 units x2 | 2.5 doses | ## Universal Mixing Calculator Use this formula for any vial size and desired concentration: **BAC Water (ml) = Vial Size (mg) Desired Concentration (mg/ml)** **Injection Volume (ml) = Desired Dose (mg) Concentration (mg/ml)** **Syringe Units = Injection Volume (ml) 100** ### Example Calculation You have a 50mg vial and want 10mg/ml concentration: - BAC water: 50mg 10mg/ml = 5.0ml - For a 4mg dose: 4mg 10mg/ml = 0.4ml = 40 units - For an 8mg dose: 8mg 10mg/ml = 0.8ml = 80 units ## Which Vial Size Should You Choose

2018;14(7S_Part_12):P688 Boada M, Lpez OL, Olazarn J, et al

Adding 2 ml of bacteriostatic water to a 5 mg vial creates a concentration of 2.5 mg per ml, or 0.25 mg per 0.1 ml (10 units on an insulin syringe)

Apr 29, 2026 Articles, Diabetes, GLP- 1 Agonist Therapy Center, GLP-1 Agonist Therapy Center, Therapies, Type 2 Diabetes, Type 2 Diabetes 1,054 views The rise of oral GLP-1 medications is changing how clinicians approach type 2 diabetes treatment