Given that some treatments for IBD can have rare but potentially serious side effects, gastroenterologists work with patients to weigh the benefits and risks of the different medicines with the risk of untreated, or undertreated, disease
Before escalating to second- or third-line therapies, clinicians should first evaluate for potential confounding factors such as non-adherence, sub-optimal drug dosing, azathioprine hypermethylation, alternative etiologies, and co-existing conditions like celiac disease, metabolic dysfunction-associated steatotic liver disease, or ASC/overlap syndromes [29, 104]
The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial
Yap, W.H
Its inhibitory dose can be below 20 g/ml (54, 55)
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