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The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1

Then 3, then 4, and next thing you know you have 10 or 20

10.1093/eurheartj/ehw386 4

[41] described a higher prevalence of sleep apnea in diabetic patients with autonomic dysfunction, positing that autonomic neuropathy may disrupt ventilatory control by modifying chemoreceptor gain or cardiovascular function

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Mario Morieri