However, susceptibility to proteolytic degradation and limited membrane permeability restrict their action to intracellular antioxidant pathways, thereby precluding the systemic immunomodulatory effects observed in other radioprotectants
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Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration
Hence, DHQ exhibits notable advantages in mitigating PF through multiple mechanisms