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However, clinical evidence available as of late 2024 is mixed and more research is needed before conclusions can be drawn as to the effectiveness of P

A patients response may depend on: Starting weight Insulin resistance Appetite patterns Hormone changes Sleep quality Stress levels Muscle mass Nutrition habits Medication tolerance Dose progression Follow-up consistency Some patients begin comparing medications after a plateau, when semaglutide or tirzepatide results may slow over time and the treatment plan needs to be reassessed

Effect: Modestly prolong endogenous GLP-1 activity

Komor, A

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Net prices of branded GLP-1s would have to come down further in order for them to be cost-saving within, say, a two-year time period