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In moving toward a systems level understanding of the MGBA and leveraging advances in microbiome science-the LBPs-it is all possible to usher in a new era of preventive and therapeutic agendas toward complex neuropsychiatric and neurodegenerative disorders

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[1] [2] [3] [20] NAD+ supplementation could prevent mitochondrial deterioration and preserve metabolic function/energy (ATP) generation by balancing age-related degradation of NAD+ and its precursor nicotinamide mononucleotide via NADases, particularly CD38

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the mimetics display profound anti-dementia and anti-PD activity, and herein are described methods for treating and/or preventing dementia and PD, and symptoms thereof, using the HGF minetics