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Quantitative gene expression analysis by Q-RT-PCR Lung tissues were homogenized, and total RNA was extracted using the RNX-Plus Kit (SinaClon, Tehran, Iran)

Both retatrutide and CJC/Ipa can cause mild fluid retention

doi: 10.1093/jnci/djp354 52 ArnbjrnssonEArnbjrnssonAOlafssonA

Patients with this type of bile acid diarrhea have significantly lower FGF19 and higher 7a-hydroxy-4-cholesten-3-one (C4) levels than healthy controls (169), which supports the hypothesis that excess synthesis of bile acids may overflow the reabsorption capacity in the ileum and hence allow bile acids to enter the colon in larger quantities

This underscores the uncertainty surrounding the long-term effects of these agents, which patients may need to take indefinitely to sustain weight loss

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