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Some contraindications include: A personal or family history of medullary thyroid carcinoma (MTC)

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Titrate: Increase gradually every few weeks as tolerated

Both the combined results of the IVW method (OR common-effect-model = 0.43 [95%CI 0.260.72], OR random-effects-model = 0.42 [95%CI 0.240.76]) and the SMR method (OR common-effect-model = 0.97 [95%CI 0.960.99], OR random-effects-model = 0.97 [95%CI 0.951.00]) showed the consistent trend with the separate results(Fig

Differences in safety perception often reflect dosing schedules, patient populations studied, and individual tolerance rather than inherent drug danger