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The supplementary in-trial analysis of all available data demonstrated similar, non-significant results for total fat mass with reductions of 3.0 kg (0.37) and 2.3 kg (0.36) for semaglutide and canagliflozin, respectively (ETD 0.71 [95% CI 1.72, 0.31])
However, no significant differences were noted in muscle fiber size or fiber size distribution across groups, indicating that gross structural preservation was maintained regardless of treatment
To further observe the transformation of peptides in living cells, we conjugated a fluorescent indicator Rhodamine B (RhoB) to peptides and synthesized RS and RC as analogs of NSBSO and NCBSO respectively (Additional file 1: Figs
ApoA1 concentration and the apoA1/apoB ratio in both groups was notably reduced, while Lp (a) and apoB concentrations in both groups increased significantly during the fasting period as presented in Table 3
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