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Folate antagonism is known to contribute to the antiproliferative effects that are important in the action of methotrexate against malignant diseases, but concomitant administration of folic or folinic acid does not diminish the anti-inflammatory potential of this agent, which suggests that other mechanisms of action might be operative

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It has been previously reported that LC (150 mg/kg/day) while combined with ginger extract (100 mg/kg/day) improves hormonal levels as well as reproductive performance in male rats [83]