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To further substantiate our working model, we re-analyzed the data obtained in our previous study showing that the silencing of LDHB results in a significant reduction in mitochondrial metabolism 11

5 Intervention strategies targeting ferroptosis in OA and future perspectives Having delineated the pathophysiological links between OA and ferroptosis, we now examine current and emerging therapeutic approaches that aim to block or mitigate ferroptosis and potentially preserve joint integrity